LFM-A13

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LFM-A13

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Cat No: 10010265

Biochemicals - Kinase Inhibitors

LFM-A13 is an inhibitor of Bruton's tyrosine kinase (BTK; IC50 = 2.5 µM).{15125} It is selective for BTK over JAK1, JAK3, IRK, EGFR, and HCK (IC50s = >278 µM for all), as well as a panel of seven serine/threonine and 10 tyrosine kinases as well as one...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2Z-cyano-N-(2,5-dibromophenyl)3-hydroxy-2-butenamide

Correlated keywords:

LFM-A-13 LFMA-13 LFMA13 JAK-1 3 PLK-1 3 Plx-1 NALM6UM1 NALM6-UM1

Product Overview:
LFM-A13 is an inhibitor of Bruton's tyrosine kinase (BTK; IC50 = 2.5 µM).{15125} It is selective for BTK over JAK1, JAK3, IRK, EGFR, and HCK (IC50s = >278 µM for all), as well as a panel of seven serine/threonine and 10 tyrosine kinases as well as one lipid kinase (IC50s = >200-500 µM), but does inhibit polo-like kinase 3 (PLK3; Ki = 7.2 µM) and Xenopus PLK1 (Plx1; IC50 = 10 µM).{15126,15124} LFM-A13 increases anti-FAS antibody-induced apoptosis in NALM-6-UM-1 acute lymphoblastic leukemia (ALL) cells.{15125} It reduces tumor growth in an MMTV/neu transgenic mouse model of breast cancer when administered at a dose of 50 mg/kg.{15124}

Size	5 mg
Shipping	dry ice
CAS Number	244240-24-2
Molecular Formula	C₁₁H₈Br₂N₂O₂
SMILES	C/C(=C(\C#N)/C(=O)Nc1cc(Br)ccc1Br)/O
Molecular Weight	360
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.