24(S)-hydroxy Cholesterol

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Cat No: 10009931

Biochemicals - Lipids

24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circula...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

cholest-5-ene-3?,24S-diol

Correlated keywords:

hydroxycholesterol 27460-27-1 nuclear receptors oxysterols neurosciences intracellular signaling agonists Alzheimer’s diseases LXR cholesterol homeostasis CYP46 brains blood blood-brain barriers circulation cells sterols biosynthesis livers LXR? LXR? nuclear upregulation genes neurological neuropathological cerbrosterin 24s-hydroxycholesterol

Product Overview:
24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further sterol biosynthesis, or be metabolized in the liver.{15406} 24(S)-hydroxy cholesterol potently activates LXRα and LXRβ nuclear receptors (EC50 = 4 and 3 μM, respectively), causing upregulation of cholesterol-lowering genes.{15406,25539,15410} In the brain, this oxysterol controls cholesterol processing to facilitate neurological repair during Alzheimer’s disease and other neuropathological conditions.{15406}

Size	1 mg
Shipping	dry ice
CAS Number	474-73-7
Molecular Formula	C₂₇H₄₆O₂
SMILES	O[C@@H]1CC2=CC[C@]3([H])[C@@](CC[C@]4([C@@]3([H])CC[C@]4([H])[C@@H](CC[C@H](O)C(C)C)C)C)([H])[C@](C)2CC1
Molecular Weight	402,7
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2907.19
UNSPSC code	12352100

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MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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