SecinH3

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SecinH3

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Cat No: 10009570

Biochemicals - Small Molecule Inhibitors

Cytohesins are small guanine nucleotide exchange factors (GEFs) that stimulate adenosine diphosphate ribosylation factors (Arfs), GTPases which control signal transduction along various intracellular pathways.{25737} SecinH3 is a selective inhibitor of...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[4-[5-(1,3-benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)-acetamide

Correlated keywords:

signals transductions inhibitors inhibits inhibitions intracellular signaling diabetes cancers cytohesins GEFs guanine nucleotide exchange factors insulin resistance hepatic drosophila steppke receptor-mediated receptors mediated cells proliferation selective adenosine diphosphate ribosylation Arfs GTPases pathways Secin H3 H 3 three blocking blocks humans mouse Sec7 Sec 7 seven domains small Arf-GEFs binds larger liver carcinoma HepG2 cells Hep G2 G 2 two prevents cytohesin-dependent dependents mice produces hepatic development regulations

Product Overview:
Cytohesins are small guanine nucleotide exchange factors (GEFs) that stimulate adenosine diphosphate ribosylation factors (Arfs), GTPases which control signal transduction along various intracellular pathways.{25737} SecinH3 is a selective inhibitor of cytohesins, blocking human, mouse, and Drosophila cytohesins with IC50 values of 2.4 to 5.6 µM.{14565} It binds the Sec7 domain of these small Arf-GEFs but does not bind Sec7 domains of larger Arf-GEFs.{25739} In human liver carcinoma HepG2 cells, SecinH3 prevents cytohesin-dependent insulin signaling.{14565} In mice, SecinH3 produces hepatic insulin resistance.{14565} Inhibition of the cytohesin GEF from Drosophila, Steppke, blocks insulin signaling and interferes with development.{25736} SecinH3 is useful for studying the diverse roles of cytohesins, including the regulation of receptor-mediated cancer cell proliferation.{25738}

Size	1 mg
Shipping	dry ice
CAS Number	853625-60-2
Molecular Formula	C₂₄H₂₀N₄O₄S
SMILES	O=C(NC1=CC=C(C2=NC(OC)=NN2C3=CC=C(OCO4)C4=C3)C=C1)CSC5=CC=CC=C5
Molecular Weight	460,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

Technical File

MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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