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Glycine Receptor Polyclonal Antibody

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Cat No: 10009399
Cayman

Glycine is an important inhibitory transmitter in the brain stem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission.{14450} The binding of glycine to its receptor...

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: 1 ea

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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • GLY inhibits inhibitors inhibition inhibitory transmitter brainstem spinal cord ligand-gated ion channels family LGICs chemical neurotransmission chloride conductance membranes hyperpolarization synapses cytoplasmic proteins gephyrin alcohol synaptic clustering NMDAR subunit antibodies antisera antiserum WB western blots blotting proteins diseases immunoblotting IHC immunohistochemistry
Product Overview:
Glycine is an important inhibitory transmitter in the brain stem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission.{14450} The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin.{14448} The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins.{14445,14449} These receptors have also been extremely useful in studies of synaptic clustering of receptors.{14447} The glycine receptor may also act in concert with an NMDAR subunit to form an excitatory receptor.{14446}
Size 1 ea
Shipping dry ice
Host Rabbit
Antigen peptide from N-terminal region of the ?1-subunit of the rat glycine receptor
Application(s)

WB and IHC (frozen sections)

Formulation Peptide affinity-purified antibody
Custom Code 3822.19
UNSPSC code 12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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