Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us
You are here :

PH Domain Leucine-rich Repeat Protein Phosphatase Blocking Peptide

  • Photo non disponible
Cat No: 10007192
Antibodies - Blocking Peptides
Cayman

To be used in conjunction with Cayman’s PHLPP polyclonal antibody (Catalog No. 10007191) to block protein-antibody complex formation during immunochemical analysis of PHLPP · Protein kinase B/Akt is critical in regulating cell growth and death. Phosph...

More
: 1 ea

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • western blotting blots signaling signalling WB IHC ICC immunohistochemistry formalin-fixed paraffin-embedded immunocytochemistry proteins kinases Akt cells growth death serine residues Ser473 C-terminal hydrophobic motifs human cancers dephosphorylates dephosphorylation reduces activity apoptosis apoptotic colon glioblastomas lines tumors brain
Product Overview:
To be used in conjunction with Cayman’s PHLPP polyclonal antibody (Catalog No. 10007191) to block protein-antibody complex formation during immunochemical analysis of PHLPP · Protein kinase B/Akt is critical in regulating cell growth and death. Phosphorylation of a serine residue (Ser473) in a C-terminal hydrophobic motif of Akt is known to be linked to some of the most common human cancers. PHLPP dephosphorylates the hydrophobic motif of Akt and thus reduces Akt activity, resulting in a increase in the number of apoptotic cells.{13717} PHLPP levels are markedly reduced in several colon cancer and glioblastoma cell lines that have elevated Akt phosphorylation. Injection of a human glioblastoma cell line overexpressing PHLPP into mice reduced tumor size by nearly 70% compared with control animals. mRNA of PHLPP is ubiquitously expressed, with highest levels found in brain.{13717}
Size 1 ea
Shipping wet ice
Formulation 200 µg of peptide in 200 µl TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Custom Code 3504.00
UNSPSC code 41105329

Click here to ask for your quote and get 15% off Cayman's products.

 

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : PH Domain Leucine-<wbr/>rich Repeat Protein Phosphatase Blocking Peptide There are 4 products.

Search