CRTH2/DP2 Receptor (N-Term) Bloc

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CRTH2/DP₂ Receptor (N-Term) Blocking Peptide

Cat No: 10004884

Antibodies - Blocking Peptides

To be used in conjunction with Cayman’s CRTH2/DP2 Receptor (N-Term) polyclonal antibody (Item No. 10004886) to block protein-antibody complex formation during immunochemical analysis of CRTH2/DP2 Prostaglandin D2 (PGD2) elicits its biological function ...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

western blotting blots signaling signalling WB IHC ICC immunohistochemistry formalin-fixed paraffin-embedded immunocytochemistry controls proteins prostaglandins PGs PGD2 synthesized PGH2 non-hematopoietic lipocalin-types biological functions G protein-coupled receptors DP1 Gi Gq subunits calcium Ca2+ cells migration up-regulate regulation molecules mRNA unglycosylateds peptides NTerm coupled 44

Product Overview:
To be used in conjunction with Cayman’s CRTH2/DP2 Receptor (N-Term) polyclonal antibody (Item No. 10004886) to block protein-antibody complex formation during immunochemical analysis of CRTH2/DP2 Prostaglandin D2 (PGD2) elicits its biological function through interaction with two distinct G protein-coupled receptors, DP1 and CRTH2/DP2. CRTH2 primarily couples to Gi or Gq subunits to mobilize Ca2+, induce cell migration, and up-regulate adhesion molecules.{11493} CRTH2 mRNA has been detected in various tissues including liver, lung, kidney, brain, heart, thymus, and spleen and in various cell lineages including both hematopoietic and non-hematopoietic cell lines.{9767} Human CRTH2 is 395 amino acids in length with an estimated molecular weight of 43 kDa. Cayman’s CRTH2/DP2 receptor (N-Term) polyclonal antibody can be used for western blot and immunohistochemical analysis of CRTH2 on samples of human, bovine, murine, and rat origin. It detects both unglycosylated and glycosylated protein at sizes ranging from 35-40 kDa to 50-70 kDa, as reported by Nagata et al., in 1999.{9770}

Size	200 µg
Shipping	dry ice
Formulation	200 µg peptide in 200 µl TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Custom Code	3504.00
UNSPSC code	41105329

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

CRTH2/DP2 Receptor (N-Term) Blocking Peptide