HIF-1? (C-Term) Polyclonal Antib

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HIF-1? (C-Term) Polyclonal Antibody

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Cat No: 10006421

Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that accumulates under low-oxygen conditions.{10948,11044} Following hypoxic stimulus and cytoplasmic accumulation, HIF-1α migrates to the nucleus where with other transcription factors, i...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

HIF-1alpha factors antibodies western blots blotting WB antisera antiserum cancers hypoxia transcription factors low-oxygen hypoxic stimulus cytoplasmic accumulation cells nucleus stress-adaptive proteins oxidative physiology tumors EPAS-1 family phosphorylation prolyl hydroxylases immunoblotting HIF1 HIF1alpha HIF1 alpha HIF-1 alpha

Product Overview:
Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that accumulates under low-oxygen conditions.{10948,11044} Following hypoxic stimulus and cytoplasmic accumulation, HIF-1α migrates to the nucleus where with other transcription factors, it drives the production of stress-adaptive proteins. This response is essential for maintenance of normal oxidative physiology, however overexpression in cancer cells promotes tumor survival.{11044,9833,9834,9835,10695} HIF-1α is an endothelial PAS domain protein 1 (EPAS-1) family member with phosphorylation dependent activities.{11043,10898} Cayman Chemical’s HIF-1α polyclonal antibody can be used for WB analysis for HIF-1α on samples from human, mouse, and simian. It is not suitable for ICC or IP. Other applications for use of this antibody have not yet been tested.

Size	1 ea
Shipping	dry ice
Host	Rabbit
Antigen	Peptide from the C-terminal region of human HIF-1?
Application(s)	IHC and WB
Formulation	500 µl of peptide affinity-purified antibody
Custom Code	3822.19
UNSPSC code	12352203

Koukourakis, M.I., Giatromanolaki, A., Skarlatos, J., et al. Hypoxia inducible factor (HIF-1? and HIF-2?) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy. Cancer Res 61 1830-1832 (2001).

Wenger, R.H.

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.