PRIMA-1MET

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PRIMA-1^MET

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Cat No: 9000487

Biochemicals - More Biochemicals

Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 (Item No. 63520) is a unique anti-oncogenic substance that re-activates the apoptotic function of mutant p53 via conformational modulation of function-specific ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

Correlated keywords:

PRIMA-1 tumor-suppressor mutants p53 apoptosis cancers thioredoxin reductases redox TrxR1 apoptosis apoptotic PRIMA1 PRIMA 1 MET mutations p53 tumors suppressors neoplastic cells oncogenic anti-oncogenic antioncogenic anti oncogenes epitopes methylayted derivatives chemotherapeutic drugs inhibits inhibitors inhibiton cellular redox balances activates activators proteins APR246 APR-246

Product Overview:
Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 (Item No. 63520) is a unique anti-oncogenic substance that re-activates the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.{9837,11275} PRIMA-1MET is a methylated derivative of PRIMA-1 that restores tumor-suppressor function to mutant p53 and induces cell death in various cancer cell lines.{26369} PRIMA-1MET can synergize with chemotherapeutic drugs to induce tumor cell apoptosis.{26370} At 25-50 µM, it can also dose-dependently inhibit thioredoxin reductase, a key regulator of cellular redox balance.{26371}

Size	5 mg
Shipping	dry ice
CAS Number	5291-32-7
Molecular Formula	C₁₀H₁₇NO₃
SMILES	O=C1C2CCN(CC2)C1(CO)COC
Molecular Weight	199,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.49
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.