Interleukin-1? (human) ELISA Kit

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Cat No: 583311

Assay Kits - Elisa

Interleukin 1 (IL-1) is a name for a family of proteins which includes IL-1α, IL-1β, ILra (Interleukin receptor antagonist) and IL-18. IL-1β is synthesized as 269 amino acid pro-cytokine that is enzymatically cleaved by IL-1β-converting enzyme (ICE) i...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

enzyme-linked IL1? IL-1? interleukins measures kits eias enzymes immunometrics immunosorbents immunoassays ELISAs interleukin-1.beta. interleukin-1beta cytokines IL.beta. ILbeta IL-.beta. IL-beta IL-1b assays IL-1?-converting Interleukin-1?-converting IL-1b-converting Interleukin-1b-converting IL-1beta-converting Interleukin-1beta-converting IL-1.beta.-converting Interleukin-1.beta.-converting ICEs mature peptides cells types macrophages monocytes astrocytes endothelial smooth muscles keratinocytes adipocytes T-cells T eosinophils amino acids cell-surfaces surfaces R1 R2 R-1 R-2 RI R-I RII R-II immunity inflammations inflammatory responses hosts responses infections injury injuries diseases states arthritis rheumatoid RA bowels IBDs shocks artherosclerosis allergic cancers sandwich

Product Overview:
Interleukin 1 (IL-1) is a name for a family of proteins which includes IL-1α, IL-1β, ILra (Interleukin receptor antagonist) and IL-18. IL-1β is synthesized as 269 amino acid pro-cytokine that is enzymatically cleaved by IL-1β-converting enzyme (ICE) into the active 154 amino acid, 17 kDa peptide mature peptide.{10662,1643} IL-1β is produced by many cell types including macrophages, monocytes, astrocytes, endothelial cells, smooth muscle cells, keratinocytes, adipocytes, T cells, and eosinophils.{7221} Although IL-1α and IL-1β exhibit only 26% amino acid identity,{10662} they bind to the same cell-surface receptors, IL-1 RI and IL-1 RII, present on a variety of cell types involved in immune or inflammatory responses.{10660,10775,10668} Normal production of IL-1 is critical for mediating host responses to infection and injury.{1643,7221} Disease states in which IL-1 actively participates include inflammatory diseases, such as arthritis, inflammatory bowel disease, and shock, as well as arteriosclerosis, allergic disease, and some types of cancer.{7221,11054}

Size	96 wells
Shipping	dry ice
Custom Code	3822.19
UNSPSC code	41116104

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.