VE-Cadherin/CD144 Polyclonal Ant

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VE-Cadherin/CD144 Polyclonal Antibody

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Cat No: 160840

VE-cadherin (vascular endothelium cadherin), also known as Cadherin-5, is an endothelial cell-specific adhesion molecule localized at intracellular junctions.{7201, 7068,7071} The protein belongs to the cadherin superfamily of adhesion molecules.{7072...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

CD-144 antiCD31 CD-31 HUVEC Cdh-5

Product Overview:
VE-cadherin (vascular endothelium cadherin), also known as Cadherin-5, is an endothelial cell-specific adhesion molecule localized at intracellular junctions.{7201, 7068,7071} The protein belongs to the cadherin superfamily of adhesion molecules.{7072} VE-cadherin plays a pivotal role in vascular structure assembly. Endothelial cells fail to organize in a vessel-like pattern if the VE-cadherin gene is disrupted.{7069} In this aspect, VE-cadherin is a critical component of a protein complex which controls endothelial cell tube formation.{7070} VE-cadherin is also critical for maintenance of the endothelium. Following disruption of endothelial cell monolayers with an anti-VE-cadherin antibody, endothelial cells rapidly resynthesize VE-cadherin in order to restore their intracellular junctions.{6997} Human VE-cadherin has a molecular mass of approximately 87,500 based on the deduced amino acid sequence and is 83% and 79% homologous to porcine and mouse VE-cadherin at the amino acid level. Cayman’s VE-Cadherin Polyclonal Antibody can be used for immunocytochemistry, immunohistochemistry, immmunoprecipitation, and Western blot applications. The antibody recognizes VE-Cadherin at 88 kDa from human, bovine, and mouse samples.

Size	500 µl
Shipping	dry ice
Host	Rabbit
Antigen	Recombinant VE-cadherin peptide fragment (amino acids 259-434)
Application(s)	ICC, IHC, IP, WB
Formulation	500 µl of protein A-purified IgG
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.