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tetramethyl Nordihydroguaiaretic Acid

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    tetramethyl Nordihydro<wbr/>guaiaretic Acid
  • tetramethyl Nordihydro<wbr/>guaiaretic Acid
Cat No: 70302
Biochemicals - Anti-Infection
Cayman

tetramethyl Nordihydroguaiaretic acid (TMNDGA) is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor. It inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter, a gene essentia...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 4-[(2R,3S)-4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxy-benzene
Correlated keywords:
  • tumors inhibitor inhibits inhibition cancers NDGAs survivin apoptosis Cdc2 HIV growing growth glioma brains antitumor organic melonomas
Product Overview:
tetramethyl Nordihydroguaiaretic acid (TMNDGA) is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor. It inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter, a gene essential for HSV replication, with IC50 values of 11 and 43.5 µM respectively{16143,16144} TMNDGA induces growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity.{16147} The in vivo growth of xenografts in numerous human tumor types was suppressed upon treatment with TMNDGA.{16146} It also inhibits the growth of mouse and human melanomas and human colon cancer in vivo without causing other tissue toxicity.{16145} TMNDGA is currently in Phase I & II clinical trials for treatment of high grade glioma brain tumors.
Size 50 mg
Shipping dry ice
CAS Number 24150-24-1
Molecular Formula C22H30O4
SMILES COc1cc(ccc1OC)CC(C)C(C)Cc1ccc(OC)c(OC)c1
Molecular Weight 358,5
Formulation A crystalline solid
Purity ≥95%
Custom Code 2916.31
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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