Oxidized Lipid HPLC Mixture

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Oxidized Lipid HPLC Mixture

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Cat No: 34004

Biochemicals - Lipids

This mixture contains the primary oxidized unsaturated fatty acid components of atherosclerotic plaques. Contents: (±)9-HODE, (±)13-HODE, (±)9-HODE cholesteryl ester, (±)13-HODE cholesteryl ester, and (±)15-HETE (5 µg each). Cholesterol and LDL partic...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

ROS peroxidation LDL atherosclerosis autoxidation reactive oxygen species (+/-)9-HODEs (+/-)13-HODEs esters (+/-)15-HETEs (+/-)-HODEs (+/-)-HETEs hydroxy fatty acids racemic (+/-)HODEs (+/-)HETEs cholesteryl esters

Product Overview:
This mixture contains the primary oxidized unsaturated fatty acid components of atherosclerotic plaques. Contents: (±)9-HODE, (±)13-HODE, (±)9-HODE cholesteryl ester, (±)13-HODE cholesteryl ester, and (±)15-HETE (5 µg each). Cholesterol and LDL particles accumulate and become oxidized in the fatty deposits of atherosclerotic placques. Contained within these lipid deposits are the racemic monohydroxylation products of both linoleic and arachidonic acid.{1126} This HPLC mixture contains the free acid (non-esterified) forms of racemic 15-HETE, 9-HODE, and 13-HODE. 15-HETE is one of 5 different regioisomers produced by the random oxygenation of arachidonic acid.{4200} (The other 4 can be purchased in HPLC Mixture Catalog. No. 34002.) The 9- and 13- HODEs are the 2 different monohydroxylated regioisomers of linoleic acid produced during random free radical oxidation. In this mixture, the HODE compounds are provided both in their free acid form, and also esterified to cholesterol. Linoleate is transported primarily as the cholesteryl ester in the LDL particle, and it is likely that the esterified form is oxidized when LDL particles are exposed to uncontrolled reactive oxygen species.{2413}

Size	1 ea
Shipping	dry ice
Formulation	A solution in ethanol
Purity	≥98% for each compound
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.