Thymosin ?4 (human, mouse, rat,

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Thymosin ?4 (human, mouse, rat, porcine, bovine) (acetate)

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Cat No: 28605

Biochemicals - Small Molecule Inhibitors

Thymosin β4 is an actin-sequestering peptide that has wound healing and anti-inflammatory activities.{47654,47655,47656} It regulates cytoskeletal rearrangement by binding to actin (Kds = 0.7 and 2.1 µM for human platelets and rabbit muscle, respectiv...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-acetyl-L-seryl-L-?-aspartyl-L-lysyl-L-prolyl-L-?-aspartyl-L-methionyl-L-alanyl-L-?-glutamyl-L-isoleucyl-L-?-glutamyl-L-lysyl-L-phenylalanyl-L-?-aspartyl-L-lysyl-L-seryl-L-lysyl-L-leucyl-L-lysyl-L-lysyl-L-threonyl-L-?-glutamyl-L-threonyl-L-glutaminyl-L-?-glutamyl-L-lysyl-L-asparaginyl-L-prolyl-L-leucyl-L-prolyl-L-seryl-L-lysyl-L-?-glutamyl-L-threonyl-L-isoleucyl-L-?-glutamyl-L-glutaminyl-L-?-glutamyl-L-lysyl-L-glutaminyl-L-alanylglycyl-L-?-glutamyl-L-serine, acetate

Correlated keywords:

77591-33-4 Timbetasin Sh-oligopeptide antiinflammatory HUVEC HT1080 TNF? NF?B CXC CXCmotif CXCL 1 2 MMP9 MMP2

Product Overview:
Thymosin β4 is an actin-sequestering peptide that has wound healing and anti-inflammatory activities.{47654,47655,47656} It regulates cytoskeletal rearrangement by binding to actin (Kds = 0.7 and 2.1 µM for human platelets and rabbit muscle, respectively) and inhibiting the polymerization of actin monomers.{47654} Thymosin β4 increases in vitro migration of human umbilical vein endothelial cells (HUVECs), keratinocytes, and coronary artery endothelial cells, but not fibroblasts, actin smooth muscle cells, neutrophils, monocytes, or HT-1080 fibrosarcoma cells, when used at concentrations ranging from 0.001 to 1 µg/ml.{47655,47657} It increases gap closure and reduces wound width in a rat full-thickness cutaneous wound model when administered at a dose of 60 µg.{47655} Thymosin β4 (1 µg/ml) inhibits TNF-α-induced NF-ĸB phosphorylation and nuclear translocation in immortalized human corneal epithelial cells and decreases the expression of chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL2, matrix metalloproteinase-9 (MMP-9), and MMP-2 in the cornea in a mouse model of sodium hydroxide-induced corneal injury when administered at a dose of 5 µg.{47656}

Size	500 µg
Shipping	dry ice
Molecular Formula	C₂₁₂H₃₅₀N₅₆O₇₈S • XC₂H₄O₂
SMILES	O=C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCCN)C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C
Molecular Weight	4963,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.