Kevetrin (hydrochloride)

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Cat No: 28288

Biochemicals - Small Molecule Activators

Kevetrin is an activator of p53.{47554,47555} It increases levels of activated p53 and expression of p21 in A549 cells and decreases expression of the transcription factor E2F1 in a variety of cell lines.{47554,47555} Kevetrin decreases cell viability...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

carbamimidothioic acid, 3-cyanopropyl ester, monohydrochloride

Correlated keywords:

500863-50-3 p 53 21 A 549 E2 F1 MDAMB231 MDAMB MB231 HT29 PC 3 HCT 15 NCIH1975 H 1975 CRL1619 LN CaP MIAPaCa Pa Ca SCC5 NSC525990 Isothioureidobutyronitrile Iso-thioureido-butyro-nitrile

Product Overview:
Kevetrin is an activator of p53.{47554,47555} It increases levels of activated p53 and expression of p21 in A549 cells and decreases expression of the transcription factor E2F1 in a variety of cell lines.{47554,47555} Kevetrin decreases cell viability in a panel of cancer cell lines with a mean IC50 value of 0.49 μM.{47556} It reduces tumor growth in MDA-MB-231, HT-29, PC3, HCT15, A549, NCI-H1975, CRL-1619, LNCaP, MIA PaCa, and SCC-5 mouse xenograft models when administered at a dose of 200 mg/kg.

Size	5 mg
Shipping	dry ice
CAS Number	66592-89-0
Molecular Formula	C₅H₉N₃S • HCl
SMILES	NC(SCCCC#N)=N.Cl
Molecular Weight	179,7
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2921.29
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.