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CAY10526

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    CAY10526
  • CAY10526
Cat No: 10010088
Cayman
€59.00
Price is excluding VAT and does not include packaging neither shipping

An inhibitor of PGE2 production through the selective modulation of mPGES-1 expression; dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells (IC50 = 1.8 µM) without affecting COX-2 expression
Prostaglandin E2 (PGE2...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 4-(benzo[b]thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one
Correlated keywords:
  • inhibitors
  • inflammation
  • pains
  • inhibits
  • inhibitions
  • prostaglandins
  • PGs
  • mPGES-1
Show more...
Product Overview:
An inhibitor of PGE2 production through the selective modulation of mPGES-1 expression; dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells (IC50 = 1.8 µM) without affecting COX-2 expression
Prostaglandin E2 (PGE2) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both cyclooxygenase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1). CAY10526 is an inhibitor of PGE2 production through the selective modulation of mPGES-1 expression. It dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 1.8 µM without any effect on COX-2 expression.
Size 1 mg
Shipping wet ice
Stability Store at -20 degrees; shelf life 730 days maximum after production
CAS Number 938069-71-7
Molecular Formula C12H7BrO3S
SMILES O=C1OC(O)C(C2=CC(C=CC=C3)=C3S2)=C1Br
Molecular Weight 311.1
Formulation A crystalline solid
Purity ≥98%
Custom Code 2930902000
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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