Histone H3K27Me2 (23-34) (triflu

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Histone H3K27Me2 (23-34) (trifluoroacetate salt)

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Cat No: 28142

Biochemicals - Peptides

Histone H3K27Me2 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences. Dimethylation of H3K27 is present on large chromatin domains across approximately 70% of total his...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-lysyl-L-alanyl-L-alanyl-L-arginyl-N6,N6-dimethyl-L-lysyl-L-seryl-L-alanyl-L-prolyl-L-alanyl-L-threonylglycylglycine, trifluoroacetate salt

Correlated keywords:

H3K27 K 27 K27 H 3 3.1 3.2 Me2 Me 2 noncell BT 164 KAARKMe2SAPATGG H-Lys-Ala-Ala-Arg-Lys(Me2)-Ser-Ala-Pro-Ala-Thr-Gly-Gly-OH

Product Overview:
Histone H3K27Me2 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences. Dimethylation of H3K27 is present on large chromatin domains across approximately 70% of total histone H3 and prevents firing of non-cell type-specific enhancers.{43874} H3K27Me2 accumulates in gene bodies of genes with low levels of expression in mouse embryonic stem cells. Histone H3K27Me2 (23-34) has been used in epitope mapping of the lupus-derived monoclonal antibody BT164.{43918}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₄₈H₈₇N₁₇O₁₅ • XCF₃COOH
SMILES	CN(C)CCCC[C@@H](C(N[C@@H](CO)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(NCC(NCC(O)=O)=O)=O)=O)C)=O)=O)C)=O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)N[H])=O)C)=O)C)=O)=O.O=C(O)C(F)(F)F
Molecular Weight	1142,3
Formulation	A solid
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.