CHF5074

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CHF5074

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Cat No: 27917

Biochemicals - More Biochemicals

CHF5074 is a modulator of γ-secretase and a derivative of flurbiprofen (Item No. 70250).{51052} It inhibits the secretion of amyloid β (1-42) (Aβ42) in H4-APP695NL human neuroglioma cells that overexpress a mutated form of amyloid precursor protein (A...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-(3',4'-dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid

Correlated keywords:

A?-42-40 H4APP695NL H4-APP-695-NL COX1 COX2 HEK-293 Tg-2576 APP-swe CS-1103 CS1103

Product Overview:
CHF5074 is a modulator of γ-secretase and a derivative of flurbiprofen (Item No. 70250).{51052} It inhibits the secretion of amyloid β (1-42) (Aβ42) in H4-APP695NL human neuroglioma cells that overexpress a mutated form of amyloid precursor protein (APP; IC50 = 41 µM) and selectively inhibits secretion of Aβ42 over Aβ40 with 79% and 14% inhibition, respectively, at 100 µM. It does not inhibit COX-1 or COX-2 when used at concentrations up to 100 and 500 µM, respectively, and does not induce Notch cleavage in HEK293 cells expressing the APP mutant APPswe at 5 µM.{51052,51053} CHF5074 decreases plasma levels of Aβ42 in the Tg2576 transgenic mouse model of Alzheimer’s disease when administered at a dose of 12.5 mg/kg per day for seven days and reduces the plaque area and number of plaques in the brain of hAPP mice when administered in the diet at 375 ppm for six months.{51052,35877} It decreases the distance traveled, but not the escape latency, in the Morris water maze in hAPP mice compared to hAPP animals administered a vehicle control.

Size	1 mg
Shipping	dry ice
CAS Number	749269-83-8
Molecular Formula	C₁₆H₁₁Cl₂FO₂
SMILES	O=C(O)C1(CC1)C2=CC(F)=C(C3=CC(Cl)=C(Cl)C=C3)C=C2
Molecular Weight	325,2
Formulation	A solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.