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C12 NBD dihydro Ceramide (d18:0/12:0)

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    C12 NBD dihydro Ceramide (d18:0/12:0)
  • C12 NBD dihydro Ceramide (d18:0/12:0)
Cat No: 10008097
Biochemicals - Labeling & Detection
Price is excluding VAT and does not include packaging neither shipping

Ceramidase catalyzes the hydrolysis of the N-acyl linkage between the fatty acid and sphingosine base in ceramide to produce sphingosine and a free fatty acid. Three isoforms of ceramidases (acid, neutral, and alkaline) have been characterized based on...


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Territorial Availability: Available through Bertin Technologies only in Europe
  • N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-dodecanamide
Correlated keywords:
  • ceramides cerimidases fluorescent fluorescence substrates N-acyl fatty acids sphingosine bases isoforms neutral alkalines catalytic pH analogs hydrolyzed hydrolysis P. aeruginosa mouse liver mammalian cells lines kinases sphingomyelin synthases N-C12-NBD-D-erthro-dihydro-Sphingosine C-12 NBD-dihydro-Ceramide (d18:0/12:0)
Product Overview:
Ceramidase catalyzes the hydrolysis of the N-acyl linkage between the fatty acid and sphingosine base in ceramide to produce sphingosine and a free fatty acid. Three isoforms of ceramidases (acid, neutral, and alkaline) have been characterized based on differences in their catalytic pH optimum.{9268,10050} C12 NBD dihydro ceramide is a fluorescent ceramide analog that contains a saturated bond in the C-4/C-5 position of the sphingosine backbone. C-12 NBD ceramide, which contains the C-4/C-5 double bond, is a fluorescent ceramidase substrate that can be used for the measurement of alkaline and neutral ceramidase activity from a variety of sources.{14063} C12 NBD dihydro ceramide may exhibit reduced activity in ceramidase assays compared to C-12 NBD ceramide. This is based on the observation that saturation of the C-4/C-5 sphingosine bond in C-16-ceramide results in approximately a 10-fold reduction in efficiency as a substrate for rat brain ceramidase compared to the unsaturated substrate.{14071} However, experimental characterization of C12 NBD dihydro ceramide as a ceramidase substrate needs to be performed.
Size 1 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 365 days
CAS Number 474943-05-0
Molecular Formula C36H63N5O6
Molecular Weight 661,9
Formulation A solution in chloroform:ethanol (1:1)
Purity ≥98%
Custom Code 2922.19
UNSPSC code 12352100

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