Pogostone

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Pogostone

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Cat No: 27812

Biochemicals - Pesticides

Pogostone is a pyranone that has been found in the essential oil of P. cablin, also known as patchouli oil, and has antifungal and insecticidal activities.{51079} It is active against a laboratory strain and clinical isolates of C. albicans (MICs = 49...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-2H-pyran-2-one

Correlated keywords:

Dhelwangin anti-fungal candida Spodoptera vulvo-vaginal

Product Overview:
Pogostone is a pyranone that has been found in the essential oil of P. cablin, also known as patchouli oil, and has antifungal and insecticidal activities.{51079} It is active against a laboratory strain and clinical isolates of C. albicans (MICs = 49 and 12-97 µg/ml, respectively). It reduces fungal load in the vagina in a mouse model of fluconazole-resistant vulvovaginal candidiasis when administered at topical doses of 1, 2, and 4 mg/kg per day or oral doses of 20, 40, and 80 mg/kg per day.{51080} Pogostone is toxic to S. exigua and S. litura larvae with LC50 values of 545.61 and 986.88 mg/L for dietary administration and 519.48 and 1,041.42 mg/L for contact application.{51081} It also has antifeedant activity against third instar larvae against S. exigua and S. litura.

Size	1 mg
Shipping	dry ice
CAS Number	23800-56-8
Molecular Formula	C₁₂H₁₆O₄
SMILES	CC(C)CCC(C1=C(O)C=C(C)OC1=O)=O
Molecular Weight	224,3
Formulation	A solid
Purity	≥98%
Custom Code	2932.20
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.