NG 012

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NG 012

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Cat No: 27509

Biochemicals - Natural Products

NG 012 is a fungal metabolite originally isolated from P. verruculosum that has fungicidal and nerve growth factor-potentiating properties.{45185,45186} It inhibits the growth of the plant pathogenic fungi B. cinerea, P. teres, P. lingam, S. sclerotio...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7R,8,11S,12,15R,16,23R,24,27R,28-decahydro-2,4,18,20-tetrahydroxy-11-(hydroxymethyl)-7,15,23,27-tetramethyl-5H,9H,13H,21H,25H-dibenzo[k,u][1,5,9,15,19]pentaoxacyclotetracosin-5,9,13,21,25-pentone

Correlated keywords:

NG012 BK 223A BK223A BK223-A 223 LL 15156a 15156 LL15156a LL15156 LL15G256a LL15G256 15G256a 15G256 a Penicillium Botrytis Pyrenophora Phoma Sclerotinia Monilinia Candida anti-fungal PC-12

Product Overview:
NG 012 is a fungal metabolite originally isolated from P. verruculosum that has fungicidal and nerve growth factor-potentiating properties.{45185,45186} It inhibits the growth of the plant pathogenic fungi B. cinerea, P. teres, P. lingam, S. sclerotiorum, and M. fructigena in vitro.{45185} NG 012 (50 μM) increases the efficacy of the antifungal miconazole (Item No. 15420) against C. albicans, reducing the IC50 value from 19.2 to 2.5 μM.{45187} It also potentiates neurite outgrowth induced by nerve growth factor (NGF) in PC12 cells in a concentration-dependent manner.{45186}

Size	500 µg
Shipping	dry ice
CAS Number	141731-76-2
Molecular Formula	C₃₂H₃₈O₁₅
SMILES	OC(C=C1O)=CC(C[C@@H](C)OC(C[C@@H](C)OC(C2=C(O)C=C(O)C=C2C[C@@H](C)OC(C[C@@H](CO)OC(C[C@@H](C)O3)=O)=O)=O)=O)=C1C3=O
Molecular Weight	662,6
Formulation	A solid
Purity	≥95%
Custom Code	2907.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.