Ginsenoside Rh1

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Ginsenoside Rh₁

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Cat No: 27318

Biochemicals - Lipids

Ginsenoside Rh1 is a steroid glycoside and saponin that has been found in red ginseng and has diverse biological activities.{47437,47438} It inhibits expression of matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-9 induced by phorbol 12-myristate 13...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3?,6?,12?)-3,12,20-trihydroxydammar-24-en-6-yl, ?-D-glucopyranoside

Correlated keywords:

A 2 Rh 1 metallo-proteinase MMP1 MMP3 MMP9 U87 MG U373 MG 87 U 373 PGE 2 E i NOS RAW264.7 Ig Rg micro-flora Lipopolysaccharide

Product Overview:
Ginsenoside Rh1 is a steroid glycoside and saponin that has been found in red ginseng and has diverse biological activities.{47437,47438} It inhibits expression of matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-9 induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in U87MG and U373MG human astroglioma cells in a concentration-dependent manner.{47438} Ginsenoside Rh1 (300 μM) also inhibits PMA-induced invasion and migration of these cell lines in Matrigel™ invasion and wound healing assays, respectively. It inhibits LPS-induced increases in nitrite accumulation, prostaglandin E2 (PGE2; Item No. 14010) synthesis, and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 cells and inhibits histamine release induced by compound 48/80 (Item No. 22173) in rat peritoneal mast cells (IC50 = 37 μM).{47439} Ginsenoside Rh1 (25 mg/kg, i.p.) inhibits IgE-induced passive cutaneous anaphylaxis reactions in mice by 87%. Ginsenoside Rh1 is also a metabolite of ginsenoside Re (Item No. 15330) and ginsenoside Rg1 (Item No. 15315) formed by intestinal microflora.{47438,25016}

Size	5 mg
Shipping	dry ice
CAS Number	63223-86-9
Molecular Formula	C₃₆H₆₂O₉
SMILES	O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@](O)(C)CC/C=C(C)/C)(C)[C@]3(C)C[C@H](O[C@@]4([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@]5([H])[C@@](CC[C@H](O)C5(C)C)(C)[C@@]3([H])C1
Molecular Weight	638,9
Formulation	A solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.