AGE (GA-Pyridine Specific) Monoc

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AGE (GA-Pyridine Specific) Monoclonal Antibody (Clone 3G2)

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Cat No: 27272

Glycolaldehyde-pyridine (GA-pyridine) is an advanced glycation end product (AGE).{15062,49055} It is formed via the reaction of GA, a product of myeloperoxidase activity, with lysine and can therefore serve as an antigenic marker of protein modificati...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

3-G-2 GAAGE myelo peroxidase

Product Overview:
Glycolaldehyde-pyridine (GA-pyridine) is an advanced glycation end product (AGE).{15062,49055} It is formed via the reaction of GA, a product of myeloperoxidase activity, with lysine and can therefore serve as an antigenic marker of protein modification resulting from myeloperoxidase activity.{15062} GA-pyridine has been detected in the tubular epithelial cells, renal vasculature, and glomerular epithelium of both healthy and diseased human kidneys, and accumulates in the glomerular mesangium of patients with renal diseases, including diabetic nephropathy, Wegener's granulomatosis, mesangial proliferative glomerulonephritis, and focal glomerular sclerosis.{49055} GA-pyridine also accumulates in the cytoplasm of foam cells and extracellularly in the atheromatous core of human atherosclerotic lesions.{15062} Cayman's AGE (GA-Pyridine Specific) Monoclonal Antibody (Clone 3G2) can be used for Western blot and ELISA applications. This antibody recognizes GA AGE-modified proteins.

Size	100 µg
Shipping	dry ice
Host	Mouse
Antigen	GA-pyridine-BSA
Clone	3G2
Isotype	IgG2b
Application(s)	ELISA, WB
Formulation	100 µg of protein G-purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.