PAR1 (1-6) (mouse, rat) (trifluo

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PAR1 (1-6) (mouse, rat) (trifluoroacetate salt)

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Cat No: 27111

Biochemicals - Receptor Pharmacology

PAR1 (1-6) is a hexapeptide that corresponds to amino acid residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat proteinase-activated receptor 1 (PAR1), residues 42-47 of the full-length mouse sequence, and residues 46-51 of the...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-seryl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-arginyl-L-asparagine, trifluoroacetate salt

Correlated keywords:

140436-67-5 PAR1AP PAR-1 IGF1R IGF1 TFA

Product Overview:
PAR1 (1-6) is a hexapeptide that corresponds to amino acid residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat proteinase-activated receptor 1 (PAR1), residues 42-47 of the full-length mouse sequence, and residues 46-51 of the full-length rat sequence.{46158,46159} PAR1 is a high-affinity thrombin receptor that induces platelet activation and deposition into thrombi as well as smooth muscle mitogenesis.{46160} Unlike thrombin, PAR1 (1-6) acts as an agonist of PAR1 in smooth muscle cells but is inactive in rodent platelets.{46161} It increases mitogenesis and the expression of the IGF-1 receptor (IGF-1R) by 47% in vascular smooth muscle cells (VSMCs), an effect that is inhibited by the thrombin inhibitor hirudin and by the protein tyrosine kinase inhibitor genistein (Item No. 10005167).{46159} PAR1 (1-6) increases histamine and β-hexosaminidase release from rat peritoneal mast cells in a concentration-dependent manner, with the maximum release at a concentration of 50 µM.{46158} It also mimics the effect of thrombin, increasing swelling-activated efflux of [3H]glutamate induced by hypoosmotic medium in astrocytes in vitro when used at concentrations ranging from 5 to 10 µM.{46162}

Size	500 µg
Shipping	dry ice
Molecular Formula	C₃₇H₅₄N₁₀O₉ • XCF₃COOH
SMILES	[H]N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O.OC(C(F)(F)F)=O
Molecular Weight	782,9
Formulation	A solid
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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MSDS

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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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