C29 - C16H15NO4 - Bertin Bioreagent

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C29

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Cat No: 27029

Biochemicals - Receptor Pharmacology

C29 is an inhibitor of toll-like receptor 2 (TLR2) signaling.{46288} It inhibits synthetic and bacterial TLR2 agonist-induced TLR2/1 and TLR2/6 signaling in HEK-293T cells expressing human TLR2 (HEK-TLR2) and THP-1 cells when used at a concentration o...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid

Correlated keywords:

C-29 2/1 2/6 HEK293T 293-T HEKTLR2 THP1 IL8 Pam-3CSK-4 Pam3-CSK4 Pam CSK My-D88 D-88 NF?B TLR-2 TLR2INC29

Product Overview:
C29 is an inhibitor of toll-like receptor 2 (TLR2) signaling.{46288} It inhibits synthetic and bacterial TLR2 agonist-induced TLR2/1 and TLR2/6 signaling in HEK-293T cells expressing human TLR2 (HEK-TLR2) and THP-1 cells when used at a concentration of 50 µM. C29 also inhibits TLR2/1 signaling in primary murine macrophages without inducing cytotoxicity. It decreases the expression of IL-8 induced by the synthetic bacterial lipopeptide TLR2 agonist Pam3CSK4 (Item No. 24126) in HEK-TLR2 cells. C29 (150 µM) inhibits the Pam3CSK4-induced interaction between TLR2 and the adapter protein MyD88, blocks MAPK activation, and decreases NF-κB activation and IκBα degradation in THP-1 cells.

Size	1 mg
Shipping	dry ice
CAS Number	363600-92-4
Molecular Formula	C₁₆H₁₅NO₄
SMILES	O=C(O)C1=CC=CC(/N=C/C2=C(O)C(OC)=CC=C2)=C1C
Molecular Weight	285,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.