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Roridin E

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    Roridin E
  • Roridin E
Cat No: 26955
Cayman

Roridin E is a macrocyclic trichothecene mycotoxin that has been found in M. verrucaria.{46163} It inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRβ, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 μM, respectively).{46164} Roridin E induces cytotox...

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Territorial Availability: Available through Bertin Technologies only in France
Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.
Special Advice: Please check regulation status before ordering; additionel fees can apply.
Synonyms:
  • (2'E,7'R)-2',3'-didehydro-7'-deoxo-2'-deoxy-7'-[(1R)-1-hydroxyethyl]-verrucarin A
Correlated keywords:
  • 30244-25-8 Myrothecium Plasmodium Baccharis FGFR-3 IGF1R 1-R H-4TG H4-TG NIH3T-3 NIH-3T3 KA31-T KA-31T PDGFR ? Roridine
Product Overview:
Roridin E is a macrocyclic trichothecene mycotoxin that has been found in M. verrucaria.{46163} It inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRβ, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 μM, respectively).{46164} Roridin E induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM) and inhibits proliferation in a panel of additional cancer cell lines (IC50s = 50s = 1.74-7.68 nM).{46166} Roridin E inhibits the growth of P. falciparum (EC50 = 0.15 ng/ml), induces phytotoxicity in duckweed and kudzu, and is toxic to mice (LD50 = 10 mg/kg, i.p.).{46163,46167} Roridin E is also produced by the plant B. coridifolia, which is associated with livestock poisoning in South America.{46167}
Size 1 mg
Shipping dry ice
CAS Number 16891-85-3
Molecular Formula C29H38O8
SMILES CC1=C[C@]2([H])[C@@]3([C@]4(C)[C@@]5(OC5)[C@](C[C@H]4OC(/C=C\C=C\[C@](OCC/C(C)=C/C(OC3)=O)([H])[C@H](O)C)=O)([H])O2)CC1
Molecular Weight 514,6
Formulation A solid
Purity ≥95%
Custom Code 2932.99
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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