Linarin

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Linarin

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Cat No: 26900

Biochemicals - Natural Products

Linarin is a flavonoid glycoside that has been found in various fruits and vegetables and has diverse biological activities.{45217,45218,45219} It potentiates cytotoxicity and apoptosis induced by tumor necrosis factor-related apoptosis-induced ligand...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7-[[6-O-(6-deoxy-?-L-mannopyranosyl)-?-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Correlated keywords:

1329-58-4 11027-51-3 11030-42-5 181586-39-0 2223047-41-2 U-87MG U87-MG 87 poly-morphonuclear NLRP3 NLRP-3 NF?B acetyl-cholienesterase acetylcholine zebra-fish linarine

Product Overview:
Linarin is a flavonoid glycoside that has been found in various fruits and vegetables and has diverse biological activities.{45217,45218,45219} It potentiates cytotoxicity and apoptosis induced by tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in U87MG human glioma cells.{45217} In vivo, linarin potentiates TRAIL-induced tumor cell apoptosis and reduction of tumor growth in a U87MG mouse xenograft model. Linarin (12.5-50 mg/kg) reduces pulmonary platelet count, edema, and macrophage, polymorphonuclear leukocyte, and lymphocyte infiltration, as well as inhibits TXNIP/NLRP3, MAPK, and NF-κB signaling in a mouse model of LPS-induced acute lung injury.{45218} It also inhibits acetylcholinesterase (AChE) and induces dyskinesia recovery by 74.5 and 88%, respectively, in a zebrafish model of Alzheimer's disease when administered in tank water at a concentration of 50 μg/ml.{45219}

Size	5 mg
Shipping	dry ice
CAS Number	480-36-4
Molecular Formula	C₂₈H₃₂O₁₄
SMILES	OC1=C(C(C=C(C2=CC=C(OC)C=C2)O3)=O)C3=CC(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)O4)=C1
Molecular Weight	592,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2907.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.