5-Fluorouracil-¹³C,¹⁵N₂

Biochemicals - Isotopically Labeled Standards

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Cat No: 26683

Biochemicals - Isotopically Labeled Standards

5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil (Item No. 14416) by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-fluoro-2,4(1H,3H)-pyrimidinedione-2-13C-1,3-15N2

Correlated keywords:

Sigma-723258 5FU 5FU13 5flurouracil

Product Overview:
5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil (Item No. 14416) by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis.{18418}

Size	1 mg
Shipping	dry ice
CAS Number	1189423-58-2
Molecular Formula	C₃[¹³C]H₃F[¹⁵N₂]O₂
SMILES	O=C1[15NH][13C]([15NH]C=C1F)=O
Molecular Weight	133,1
Formulation	A solid
Purity	≥95%
Custom Code	3822.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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