Ganoderic Acid A

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Ganoderic Acid A

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Cat No: 26674

Biochemicals - Natural Products

Ganoderic acid A is a triterpene that has been found in Ganoderma and has diverse biological activities.{47541,47542,47543,47544,47545} It reduces cell viability, expression of superoxide dismutase 1 (SOD1), SOD2, and SOD3, and production of reactive ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(25R)-7?,15?-dihydroxy-3,11,23-trioxo-lanost-8-en-26-oic acid

Correlated keywords:

tri-terpene SOD 2 3 PC H9 c2 cardio-myocytes NF?B TNF? IL1? IL6 BA LF interleukin

Product Overview:
Ganoderic acid A is a triterpene that has been found in Ganoderma and has diverse biological activities.{47541,47542,47543,47544,47545} It reduces cell viability, expression of superoxide dismutase 1 (SOD1), SOD2, and SOD3, and production of reactive oxygen species (ROS) in PC3 prostate cancer cells.{47541} Ganoderic acid A (2-100 μg/ml) reduces hypoxia-induced apoptosis in H9c2 cardiomyocytes.{47542} It inhibits LPS-induced activation of NF-κB, release of TNF-α, IL-1β, and IL-6, and mitochondrial activity in primary mouse cortical microglia.{47543} Ganoderic acid A (20 and 40 mg/kg) reduces lung myeloperoxidase (MPO) activity, neutrophil infiltration, and NF-κB signaling, as well as bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and IL-6 in a mouse model of LPS-induced lung injury.{47544} It also reduces weight gain and hepatic lipid accumulation and improves insulin sensitivity in a mouse model of high-fat diet-induced obesity.{47545}

Size	5 mg
Shipping	dry ice
CAS Number	81907-62-2
Molecular Formula	C₃₀H₄₄O₇
SMILES	O=C1CC[C@@]2(C)[C@](C[C@H](O)C([C@@]([C@@H](O)C[C@]3([H])[C@H](C)CC(C[C@@H](C)C(O)=O)=O)(C)[C@]3(C)C4)=C2C4=O)([H])C1(C)C
Molecular Weight	516,7
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2914.50
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.