4-Hydroxyphenylacetic Acid

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Cat No: 26613

Biochemicals - More Biochemicals

4-Hydroxyphenylacetic acid is a phenolic acid with anti-inflammatory activity.{46255} It is formed via microbial metabolism of aromatic amino acids and polyphenolic compounds, including flavonoid glycosides, by gut microbiota.{46256,46257,46258} 4-Hyd...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-hydroxy-benzeneacetic acid

Correlated keywords:

NSC25066 NSC27460 benzene acetic Hydroxy phenylacetic phenyl antiinflammatory TNF? IL1? IL6 AA tumor necrosis factor interleukin 4HPAA 4HPA pHPAA HPA

Product Overview:
4-Hydroxyphenylacetic acid is a phenolic acid with anti-inflammatory activity.{46255} It is formed via microbial metabolism of aromatic amino acids and polyphenolic compounds, including flavonoid glycosides, by gut microbiota.{46256,46257,46258} 4-Hydroxyphenylacetic acid (100 mg/kg) inhibits seawater instillation-induced increases in TNF-α, IL-1β, and IL-6 levels in lung tissue and white blood cell numbers in bronchoalveolar lavage fluid (BALF) and prevents lung edema in a rat model of acute lung injury.{46255} Levels of 4-hydroxyphenylacetic acid are increased and decreased in serum and urine, respectively, in rats fed a high-fat diet.{46256} Serum levels of 4-hydroxyphenylacetic acid are increased in patients with stage III pancreatic cancer.{46259}

Size	25 g
Shipping	dry ice
CAS Number	156-38-7
Molecular Formula	C₈H₈O₃
SMILES	OC1=CC=C(CC(O)=O)C=C1
Molecular Weight	152,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.