Rilpivirine-d6 (hydrochloride)

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Rilpivirine-d₆ (hydrochloride)

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Cat No: 26520

Rilpivirine-d6 is intended for use as an internal standard for the quantification of rilpivirine (Item No. 21559) by GC- or LC-MS. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of wild-type HIV with an EC...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-di(methyl-d3)phenyl]amino]-2-pyrimidinyl]amino]-benzonitrile, monohydrochloride

Correlated keywords:

1312424-26-2 deuterated deuterium GCMS LCMS nonnucleoside WT L-100I L100-I 100 103 K-103N K103-N V-106A V106-A 106 G-190A G190-A S 190 R278474 R-278474 TMC278 TMC-278 HIV1

Product Overview:
Rilpivirine-d6 is intended for use as an internal standard for the quantification of rilpivirine (Item No. 21559) by GC- or LC-MS. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of wild-type HIV with an EC50 value of 0.51 nM.{35241} It is active against NNRTI-resistant HIV strains with EC50 values of less than 1 nM for L100I, K103N, V106A, G190A, and G190S mutants in vitro. Rilpivirine also reduces growth of greater than 80% of 1,500 NNRTI-resistant clinical isolates (EC50s = In vivo, rilpivirine, when used in combination with cabotegravir, lamivudine (Item No. 18514), and abcavir, reduces the plasma viral titer in HIV-1 infected humanized mice.{35242}

Size	500 µg
Shipping	dry ice
Molecular Formula	C₂₂H₁₂D₆N₆ • HCl
SMILES	[2H]C([2H])([2H])C(C=C(/C=C/C#N)C=C1C([2H])([2H])[2H])=C1NC2=NC(NC3=CC=C(C#N)C=C3)=NC=C2.Cl
Molecular Weight	408,9
Formulation	A solid
Purity	≥99% deuterated forms (d1-d6)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.