Fenretinide-d4

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Fenretinide-d₄

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Cat No: 26489

Biochemicals - Receptor Pharmacology

Fenretinide is intended for use as an internal standard for the quantification of fenretinide (Item No. 17688) by GC- or LC-MS. Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC5...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(4-hydroxyphenyl-2,3,5,6-d4)-retinamide

Correlated keywords:

CAov3 OVCAR3 SK-OV-3 MCL1 antiapoptotic proapoptotic RAR? Ro 22-4667 224667 Ro224667 MK-4016 MK4016 PKC ? PK C? RAR SKOV hydroxy phenylamide 4HPR deuterated deuterium GCMS LCMS

Product Overview:
Fenretinide is intended for use as an internal standard for the quantification of fenretinide (Item No. 17688) by GC- or LC-MS. Fenretinide is a synthetic derivative of retinoic acid (Item No. 11017) and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).{39681} It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.{22943} At 5-20 µM, fenretinide selectively activates retinoic acid receptor γ (RARγ) and is reported to inhibit the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells with IC50 values of 3.7, 6.9, and 8.2 µM, respectively.{24737,17895} It also increases activity of serine palmitoyl transferase (SPT) by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM).{12547} Fenretinide prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle.{39682} In vivo, fenretinide (10 mg/ml in drinking water) reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription.{39682}

Size	500 µg
Shipping	dry ice
CAS Number	2118244-64-5
Molecular Formula	C₂₆H₂₉D₄NO₂
SMILES	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(NC2=C([2H])C([2H])=C(O)C([2H])=C2[2H])=O)C(C)(C)CCC1
Molecular Weight	395,6
Formulation	A solid
Purity	≥99% deuterated forms (d1-d4)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.