YTHDC2 (human, recombinant)

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Cat No: 26344

Proteins - Enzymes

YTH domain containing 2 (YTHDC2) is an ATP-dependent 3’-5’ RNA helicase and a member of the DExD/H-box family of helicases.{42792} YTHDC2 contains ATP binding, ATP hydrolysis, and RNA binding motifs.{42792} The YTH domain binds to N6-methyladenosine-m...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

YTHDC-2 NS Huh-7 Y2KD116 HCT Escherichia GSTTEV mRNA hYTHDC

Product Overview:
YTH domain containing 2 (YTHDC2) is an ATP-dependent 3’-5’ RNA helicase and a member of the DExD/H-box family of helicases.{42792} YTHDC2 contains ATP binding, ATP hydrolysis, and RNA binding motifs.{42792} The YTH domain binds to N6-methyladenosine-modified germline messenger RNA to regulate meiotic gene expression in mammalian germ cells, mediating the mitotic-to-meiotic transition in mouse germ cells.{42795,42794} Ythdc2-/- male and female mice show disrupted meiotic prophase progression.{42794} Male Ythdc2-/- mice have degraded germ cells and lack mature spermatozoa, while female Ythdc2-/- mice lack developing ovarian follicles and have few germ cells. YTHDC2 also facilitates hepatitis C virus (HCV) genome replication by binding to the HCV replication cofactor cyclophilin B and the HCV RNA polymerase non-structural protein 5B (NS5B).{42793} YTHDC2 downregulation inhibits proliferation in Huh7 hepatocellular carcinoma cells and reduces metastasis a Y2KD-116 mouse xenograft model using HCT116 cells in which YTHDC2 is downregulated.{42793,35924} The expression of YTHDC2 in isolated human tumor tissue is positively correlated with tumor stage and lymph node metastasis.{35924}

Size	100 µg
Shipping	dry ice
Formulation	50 mM HEPES, pH 8.0, with 150 mM sodium chloride and 10% glycerol
Purity	≥85% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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