Bergapten

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Bergapten

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Cat No: 26254

Biochemicals - Natural Products

Bergapten is a furanocoumarin derivative that has been found in grapefruit peel oil and has diverse biological activities.{22311,47434,47435,47436} It decreases the viability of DLD-1 and LoVo colorectal cancer cells in a concentration-dependent manne...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one

Correlated keywords:

NSC95437 5Methoxypsoralen Bergaptan Bergaptene Geralen Psoraderm Majudin DLD1 Lo Vo G 1 0 G0G1 photo-sensitizing TNF? IL1? P 450 3A4 5MOP Methoxy-psoralen furanocoumarin furano-coumarin Demethoxyisoimpinellin Demethoxy-isoimpinellin

Product Overview:
Bergapten is a furanocoumarin derivative that has been found in grapefruit peel oil and has diverse biological activities.{22311,47434,47435,47436} It decreases the viability of DLD-1 and LoVo colorectal cancer cells in a concentration-dependent manner, halts the cell cycle at the G0/G1 and sub-G1 phases, and induces apoptosis when used at a concentration of 50 μM.{47434} Bergapten has photosensitizing activity and increases the number of sunburn cells in guinea pig skin in response to UVA radiation.{47435} It increases the pain threshold in assays for mechanical, cold, and hot allodynia, as well as mechanical hyperalgesia, in a rat model of vincristine-induced neuropathic pain when administered at a dose of 10 mg/kg. {47436} Bergapten inhibits vincristine-induced increases in plasma TNF-α and IL-1β levels and decreases in glutathione (GSH) levels in the spinal cord and sciatic nerve in rats. It also inhibits the cytochrome P450 (CYP) isoform CYP3A4 with IC50 value of approximately 25 μM in human liver microsomes.{22311}

Size	500 mg
Shipping	dry ice
CAS Number	484-20-8
Molecular Formula	C₁₂H₈O₄
SMILES	O=C1C=CC2=C(OC)C3=C(OC=C3)C=C2O1
Molecular Weight	216,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.20
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.