p-chloro Phenylalanine

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Cat No: 26168

Biochemicals - Small Molecule Inhibitors

p-chloro Phenylalanine is an inhibitor of tryptophan hydroxylase (Ki = 300 µM).{47198} It acts as a competitive inhibitor in vitro and an irreversible inhibitor in vivo. It depletes serotonin to undetectable levels in rats after six days when administ...

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Territorial Availability: Available through Bertin Technologies only in France

                                            Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.
                    

Special Advice: Dangerous Good in said quantity, not available for sale.

Synonyms:

4-chloro-phenylalanine

Correlated keywords:

1991-78-2 NSC77370 CP10188 Fenchlonine Fenclonin PC PA Alanine parachloro para Chlorophenylalanine Fenclonina Fencloninum Parachlorophenylalanine

Product Overview:
p-chloro Phenylalanine is an inhibitor of tryptophan hydroxylase (Ki = 300 µM).{47198} It acts as a competitive inhibitor in vitro and an irreversible inhibitor in vivo. It depletes serotonin to undetectable levels in rats after six days when administered at a dose of 300 mg/kg. p-chloro Phenylalanine has commonly been used to deplete brain serotonin levels in animal studies of the serotonergic system and its involvement in depressive-like behavior, reward learning, Parkinson’s disease, and pain.{47199,47200,47201,47202}

Size	50 g
Shipping	dry ice
CAS Number	7424-00-2
Molecular Formula	C₉H₁₀ClNO₂
SMILES	ClC1=CC=C(CC(N)C(O)=O)C=C1
Molecular Weight	199,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.