Sulfisoxazole

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Sulfisoxazole

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Cat No: 25980

Sulfisoxazole is a sulfonamide antibiotic and nonpeptide endothelin (ET) receptor antagonist (IC50s = 0.6 and 22 μM for the ETA and ETB receptors, respectively).{47039,47040} It inhibits the growth of Gram-positive and Gram-negative bacteria in vitro,...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-amino-N-(3,4-dimethyl-5-isoxazolyl)-benzenesulfonamide

Correlated keywords:

207522-06-3 Streptococcus Bacillus Staphylococcus Escherichia Klebsiella anti-biotic non-peptide ET1 TE-671 Alphazole Amidoxal Chemouag Dorsulfan Warthausen Entusul Gantrisin Gantrisona Gantrizin Gantrosan Isoxamin NSC13120 NSC33807 NSC38588 NSC683536 Neazolin Neoxazol Norilgan-S Pancid Roxosul Sosol Soxazole Soxisol Soxomide Stansin Sulbio Sulfadimethylisoxazole Sulfafurazol Sulfagan Sulfaisoxazole Sulfalar Sulfasol Sulfazin Sulfisoxazol Sulfoxol Sulphafurazole Sulphisoxazole Sulsoxin Thiasin Unisulf Uritrisin

Product Overview:
Sulfisoxazole is a sulfonamide antibiotic and nonpeptide endothelin (ET) receptor antagonist (IC50s = 0.6 and 22 μM for the ETA and ETB receptors, respectively).{47039,47040} It inhibits the growth of Gram-positive and Gram-negative bacteria in vitro, including S. pneumoniae, B. subtilis, S. epidermidis, E. coli, and K. pneumoniae (MICs = 1.95, 0.98, 7.81, 62.5, and 7.81 μg/mL, respectively).{47041} Sulfisoxazole inhibits phosphoinositide turnover stimulated by endothelin-1 (ET-1; Item No. 24127) in TE671 cells. It inhibits ET-induced contraction of rat pulmonary artery rings ex vivo when used at concentrations of 0.1 and 1 mM.{47040} Sulfisoxazole (1,000 mg/kg per day) reduces atrial natriuretic peptide levels in myocytes and plasma and increases survival in a rat model of pulmonary hypertension induced by monocrotaline (MCT; Item No. 16666) as well as blocks MCT-induced increases in pulmonary artery blood pressure when administered at doses of 300 and 1,000 mg/kg.

Size	1 g
Shipping	dry ice
CAS Number	127-69-5
Molecular Formula	C₁₁H₁₃N₃O₃S
SMILES	NC1=CC=C(S(NC2=C(C)C(C)=NO2)(=O)=O)C=C1
Molecular Weight	267,3
Formulation	A solid
Purity	≥98%
Custom Code	2935.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.