Olmesartan Medoxomil-d6

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Olmesartan Medoxomil-d₆

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Cat No: 25759

Biochemicals - Isotopically Labeled Standards

Olmesartan medoxomil-d6 is intended for use as an internal standard for the quantification of olmesartan medoxomil (Item No. 11614) by GC- or LC-MS. Olmesartan medoxomil is an orally bioavailable prodrug form of olmesartan (Item No. 23412), a nonpepti...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-(1-hydroxy-1-methylethyl-d6)-2-propyl-1-[[2’-(2H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

Correlated keywords:

deuterated deuterium GCMS LCMS AT-1 2 CS866 CS-866 FA

Product Overview:
Olmesartan medoxomil-d6 is intended for use as an internal standard for the quantification of olmesartan medoxomil (Item No. 11614) by GC- or LC-MS. Olmesartan medoxomil is an orally bioavailable prodrug form of olmesartan (Item No. 23412), a nonpeptide angiotensin II antagonist that is selective for the angiotensin 1 (AT1) receptor over the AT2 receptor.{20965} Olmesartan medoxomil (0.1 mg/kg) inhibits the angiotensin II pressor response in normotensive rats. It reduces both systolic and diastolic blood pressure in fructose-fed rats, a model of insulin resistance, when administered at a dose of 10 mg/kg per day, as well as in chow-fed control animals when administered at a dose of 11.4 mg/kg per day.{42446} Olmesartan medoxomil also inhibits increases in plasma levels of triglycerides and non-esterified fatty acids in fructose-fed rats. Formulations containing olmesartan medoxomil have been used in the treatment of hypertension.

Size	500 µg
Shipping	dry ice
CAS Number	1127298-67-2
Molecular Formula	C₂₉H₂₄D₆N₆O₆
SMILES	CCCC1=NC(C(C([2H])([2H])[2H])(O)C([2H])([2H])[2H])=C(C(OCC(O2)=C(C)OC2=O)=O)N1CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3
Molecular Weight	564,6
Formulation	A solid
Purity	≥99% deuterated forms (d1-d6)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.