Nonivamide

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Nonivamide

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Cat No: 25328

Biochemicals - Ion Channel Modulation

Nonivamide is a transient receptor potential vanilloid type 1 (TRPV1) agonist and an analog of capsaicin (Item Nos. 92350
10010743) that has been isolated from Capsicum species.{41887,41890} It is toxic to NHBE, BEAS-2B, and BEAS-2B cells overexpres...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide

Correlated keywords:

618-92-8, 60806-29-3, 497080-86-1 NSC172795 Vanillylpelargonamide Nonylic Nonanoylvanillyl Vanillyl nonylamide Nonylvanylamide TRPV-1 SHSY5Y BEAS2B TRPV-1 GADD-153 PAVA

Product Overview:
Nonivamide is a transient receptor potential vanilloid type 1 (TRPV1) agonist and an analog of capsaicin (Item Nos. 92350
10010743) that has been isolated from Capsicum species.{41887,41890} It is toxic to NHBE, BEAS-2B, and BEAS-2B cells overexpressing TRPV1 (TRPV1-OE; LC50s = 160, 115, and 1 µM, respectively), increases calcium flux in TRPV1-OE cells (EC50 = 1.4 µM), and increases GADD153 mRNA expression by 7- and 6-fold when used at concentrations of 2 and 20 µM, respectively.{41890} Nonivamide (1 µM) also increases the release of dopamine and serotonin from SH-SY5Y cells in a calcium-dependent and TRPV1-independent manner.{41888} In mice, it reduces respiration when inhaled and is toxic with LD50 values of 200 and 413 mg/kg for oral and inhaled administration, respectively.{41889} Formulations containing nonivamide have been used in pepper spray weaponry for riot control.

Size	1 g
Shipping	dry ice
CAS Number	2444-46-4
Molecular Formula	C₁₇H₂₇NO₃
SMILES	COC1=C(O)C=CC(CNC(CCCCCCCC)=O)=C1
Molecular Weight	293,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.