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Senecionine

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    Senecionine
  • Senecionine
Cat No: 25145
Biochemicals - Natural Products
Cayman

Senecionine is a pyrrolizidine alkaloid that has been found in S. vulgaris and has hepatotoxic properties.{48022} It is metabolized by the cytochrome P450 (CYP) isoform CYP3A in the liver to the detoxification product senecionine N-oxide and reactive ...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (3Z,5R,6R,14aR,14bR)-3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione
Correlated keywords:
  • 11002-70-3 11024-76-3 Aureine NSC89935 Senecionin Strongylus CYP-3A 450 CYP450
Product Overview:
Senecionine is a pyrrolizidine alkaloid that has been found in S. vulgaris and has hepatotoxic properties.{48022} It is metabolized by the cytochrome P450 (CYP) isoform CYP3A in the liver to the detoxification product senecionine N-oxide and reactive metabolites including dehydropyrrolizidine alkaloids and dehydrotetronecine.{48023,48024} Senecionine (20 μM) induces mitochondrial depolarization and fragmentation in primary cultured mouse hepatocytes and increases apoptosis in a concentration-dependent manner.{48023} In rats, senecionine (35 mg/kg, p.o.) induces liver injury, increases serum levels of bilirubin (Item No. 17161) and various bile acids, including taurocholic acid, glycocholic acid, and deoxycholic acid, and increases the activity of alanine aminotransferase and aspartate aminotransferase in serum.{48022} Senecionine-induced hepatotoxicity is associated with lipid peroxidation and glutathione depletion.
Size 1 mg
Shipping dry ice
CAS Number 130-01-8
Molecular Formula C18H25NO5
SMILES O=C(/C(C[C@@H](C)[C@@]1(C)O)=C\C)O[C@]2([H])CCN3[C@]2([H])C(COC1=O)=CC3
Molecular Weight 335,4
Formulation A crystalline solid
Purity ≥98%
Custom Code 2914.50
UNSPSC code 12352100

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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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