Chicoric Acid

Confirm delete?

Chicoric Acid

Zoom

Cat No: 24960

Chicoric acid is a dicaffeoyl ester that has been found in C. intybus with diverse biological activities.{43186} Chicoric acid (50-200 μg/ml) dose-dependently reduces the viability of Caco-2 and HCT116 human colorectal cancer cells.{43182} It inhibits...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2R,3R)-2,3-bis[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-butanedioic acid

Correlated keywords:

6537-80-0 Caco2 Cichorium NSC99173 trans-Caffeoyltartaric (-) (-)-

Product Overview:
Chicoric acid is a dicaffeoyl ester that has been found in C. intybus with diverse biological activities.{43186} Chicoric acid (50-200 μg/ml) dose-dependently reduces the viability of Caco-2 and HCT116 human colorectal cancer cells.{43182} It inhibits HIV integrase activities, including 3'-processing of a DNA oligonucleotide and integration with template DNA (IC50s = 1.1 and 0.8 μM, respectively).{43183} Chicoric acid (0.5-10 μM) noncompetitively inhibits integration of HIV DNA by HIV integrase and, at concentrations greater than or equal to 5 μM, inhibits HIV entry into H9 cells.{43184} Oral administration of chicoric acid (10 and 30 mg/kg) reduces hepatic lipid accumulation, lipid peroxidation, and fibrosis, inhibits production of pro-inflammatory cytokines and activation of NF-kB, and activates the AMPK signaling pathway in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet.{43589} Chicoric acid (2 mg/kg) also reduces blood glucose levels by 54% in mice with streptozotocin-induced diabetes.{43185}

Size	5 mg
Shipping	dry ice
CAS Number	70831-56-0
Molecular Formula	C₂₂H₁₈O₁₂
SMILES	OC1=CC=C(/C=C/C(O[C@@H](C(O)=O)[C@H](C(O)=O)OC(/C=C/C2=CC(O)=C(O)C=C2)=O)=O)C=C1O
Molecular Weight	474,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2907.29
UNSPSC code	12352100

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.