?-Endorphin (1-26) (human) (trif

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?-Endorphin (1-26) (human) (trifluoroacetate salt)

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Cat No: 24956

Biochemicals - Peptides

β-endorphin (1-26) is a neuropeptide found in rat hippocampus, brain stem, and pituitary.{36567} It is also present in the human hypothalamus, where it comprises approximately 13.1% of total β-endorphin.{36566} β-endorphin (1-26) is an opioid receptor...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

85251-33-8 68102-99-8 neuro-peptide anti-nociceptive norBNI

Product Overview:
β-endorphin (1-26) is a neuropeptide found in rat hippocampus, brain stem, and pituitary.{36567} It is also present in the human hypothalamus, where it comprises approximately 13.1% of total β-endorphin.{36566} β-endorphin (1-26) is an opioid receptor agonist that inhibits potassium-induced norepinephrine (NE) release in rat cortical slices (IC50 = 2.5 nM).{42040} It reverses inhibition of potassium-induced NE release from rat cortical slices induced by the opioid antagonists naloxone (Item No. 15594), CTOP, norbinaltorphimine (nor-BNI), and naltrindole (Item No. 9000705; pA2s = 7.59-8.63). In vivo, β-endorphin (1-26) (10 μg, i.c.v.) induces transient bradycardia in anesthetized rats.{42041} Intracerebroventricular administration of β-endorphin (1-26) increases the latency to tail withdrawal in response to thermal stimulation in mice with a median antinociceptive dose (AD50) of 1.57 μg per animal.{42042}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₁₃₀H₂₀₈N₃₂O₃₈S • XCF₃COOH
SMILES	O=C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N1CCC[C@H]1C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(C)C)C(N
Molecular Weight	2859,3
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.