Orexin B amide (human) (trifluor

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Orexin B amide (human) (trifluoroacetate salt)

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Cat No: 24765

Biochemicals - Peptides

Orexin B is a hypothalamic neuropeptide that regulates feeding behavior, wakefulness, and behavior under situations of high motivational relevance.{39620} It is an agonist of orexin (OX) receptors with IC50 values of 420 and 36 nM for human recombinan...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methioninamide, trifluoroacetate salt

Correlated keywords:

OX-1 2 205640-91-1 TFA

Product Overview:
Orexin B is a hypothalamic neuropeptide that regulates feeding behavior, wakefulness, and behavior under situations of high motivational relevance.{39620} It is an agonist of orexin (OX) receptors with IC50 values of 420 and 36 nM for human recombinant OX1 and OX2 receptors, respectively, expressed in CHO cells.{17937} It induces transient increases in intracellular calcium in CHO cells stably expressing OX1 and OX2 (EC50s = 2,500 and 60 nM, respectively) and in primary rat ventral tegmental area (VTA) dopaminergic neurons.{17937,39617} Orexin B stimulates arachidonic acid (Item No. 90010) release from CHO cells expressing human recombinant OX1 (EC50 = 4.17 nM).{39618} It also stimulates food intake in freely feeding mice and goldfish when administered at intracerebroventricular doses of 30 nmol and 10 ng/g, respectively.{17937,39619}

Size	500 µg
Shipping	dry ice
Molecular Formula	C₁₂₃H₂₁₂N₄₄O₃₅S • XCF₃COOH
SMILES	NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(N)=O)NC(CNC([C@H](CO)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CC(C)
Molecular Weight	2899,3
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

Technical File

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.