Neuropeptide Y (13-36) (human, r

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Neuropeptide Y (13-36) (human, rat) (trifluoroacetate salt)

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Cat No: 24714

Biochemicals - Peptides

Neuropeptide Y (NPY) (13-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.{5565} NPY (13-36) is an agonist of the NPY receptor Y2 with Ki values of 1....

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

CA-3 Y-2 1 4 5 122341-40-6

Product Overview:
Neuropeptide Y (NPY) (13-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.{5565} NPY (13-36) is an agonist of the NPY receptor Y2 with Ki values of 1.28 and 2.62 nM for the rat recombinant receptor in CHO cells and in rat jejunal crypt cell membranes, respectively.{41607} It inhibits forskolin-induced cAMP accumulation with EC50 values of 300, 2.2, >1,000, and 20 at Y1, Y2, Y4, and Y5 receptors, respectively, in vitro .{41608} NPY (13-36) inhibits basal short circuit currents (EC50 = ~2 µM) and electrical field stimulated-secretory responses in isolated rat jejunal mucosa (EC50 = ~200 nM) but does so less potently than NPY (Item Nos. 24716
15071).{41609} NPY (13-36) also reduces the frequency of spontaneous excitatory postsynaptic currents (EPSCs) in the CA3 region of hippocampal slices from wild-type but not Y5 receptor knockout mice.{41610}

Size	500 µg
Shipping	dry ice
Molecular Formula	C₁₃₄H₂₀₇N₄₁O₃₆S • XCF₃COOH
SMILES	NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@]([C@@H](C)O)([H])NC([C@@]([C@H](CC)C)([H])NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)N
Molecular Weight	3000,4
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.