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Vapreotide (trifluoroacetate salt)

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    Vapreotide (trifluoroacetate salt)
  • Vapreotide (trifluoroacetate salt)
Cat No: 24558
Biochemicals - Receptor Pharmacology
Cayman

Vapreotide is a peptide neurokinin-1 receptor (NK1) antagonist and analog of somatostatin (IC50 = 330 nM in a radioligand binding assay).{39493} It inhibits increases in vascular permeability stimulated by substance P (Item No. 24035) in a concentrati...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-tryptophanamide, cyclic (2?7)-disulfide, trifluoroacetate salt
Correlated keywords:
  • 103222-11-3 anti-nociceptive SKES1 ES1 SKES RC160 BMY41606 NK-1
Product Overview:
Vapreotide is a peptide neurokinin-1 receptor (NK1) antagonist and analog of somatostatin (IC50 = 330 nM in a radioligand binding assay).{39493} It inhibits increases in vascular permeability stimulated by substance P (Item No. 24035) in a concentration-dependent manner in isolated guinea pig trachea and main bronchi. Vapreotide (8 nmol per animal) reduces substance P-induced biting and scratching in mice. It increases reaction time to heat stimuli in the hot plate and tail flick tests when administered at a dose of 512 μg/kg, indicating antinociceptive activity in mice.{39494} Vapreotide reduces plasma growth hormone (GH) increases induced by phenobarbital (Item Nos. 9001494
20987), morphine (Item No. ISO60147), and chlorpromazine (Item No. 16129), hypoglycemia-induced glucagon elevation, and glucose-induced insulin secretion in rats.{39495} It also decreases tumor weight and volume in a hamster model of pancreatic ductal adenocarcinoma and suppresses tumor growth and reduces GH secretion in SK-ES-1 and MNNG/HOS osteosarcoma mouse xenograft models.{39496,39497}
Size 500 µg
Shipping dry ice
Molecular Formula C57H70N12O9S2 • XCF3COOH
SMILES O=C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O)=O)CSSC[C@H](NC([C@H](N)CC3=CC=CC=C3)=O)C4=O)=O)[C@H](CCCCN)NC([C@@H](CC5=CNC6=C5C=CC=C6)NC([C@@](CC7=CC=C(O)C=C7)([H])N4)=O)=O.FC(F)(C(O)=O)F
Molecular Weight 1131,4
Formulation A lyophilized powder
Purity ≥95%
Custom Code 3504.00
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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