Neuromedin S (rat) (trifluoroace

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Neuromedin S (rat) (trifluoroacetate salt)

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Cat No: 24547

Biochemicals - Peptides

Neuromedin S is a neuropeptide agonist of the neuromedin U (NMU) receptors that increases calcium concentrations in CHO cells overexpressing NMU1 and NMU2 (EC50s = 65 and 91 pM, respectively).{36532} Neuromedin S (1 nmol, i.c.v.) induces phase shifts ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-leucyl-L-prolyl-L-arginyl-L-leucyl-L-leucyl-L-histidyl-L-threonyl-L-?-aspartyl-L-seryl-L-arginyl-L-methionyl-L-alanyl-L-threonyl-L-isoleucyl-L-?-aspartyl-L-phenylalanyl-L-prolyl-L-lysyl-L-lysyl-L-?-aspartyl-L-prolyl-L-threonyl-L-threonyl-L-seryl-L-leucylglycyl-L-arginyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-L-aspartamide, trifluoroacetate salt

Correlated keywords:

NMU-1 2 Chinese hamster ovary NMS 843782-19-4 NPY

Product Overview:
Neuromedin S is a neuropeptide agonist of the neuromedin U (NMU) receptors that increases calcium concentrations in CHO cells overexpressing NMU1 and NMU2 (EC50s = 65 and 91 pM, respectively).{36532} Neuromedin S (1 nmol, i.c.v.) induces phase shifts in the circadian rhythm of locomotor activity in rats without altering the circadian period length.{36532} It also suppresses food and water intake in a dose-dependent manner when administered to rats during the dark period at doses ranging from 0.1 to 5 nmol.{36533} Co-administration of neuromedin S (1 nmol, i.c.v.) inhibits the ability of neuropeptide Y (Item Nos. 15071
24716), ghrelin (Item No. 24458), and agouti-related protein (ARP) to stimulate food intake in rats by greater than 50%. Neuromedin S (0.2 nmol, i.c.v.) increases vasopressin levels in rat plasma within five minutes to levels five times greater than a saline control and decreases urinary volume by 25% during the dark period.{36534}

Size	500 µg
Shipping	dry ice
Molecular Formula	C₁₉₃H₃₀₇N₅₇O₄₉S • XCF₃COOH
SMILES	NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H]1CCCN1C([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@H](CCCNC(N)=N)NC(CNC([C@H](CC(C)C)NC([C@H](CO)NC([C@@]([C@@H](C)O)([H])NC([C@@]([C@@H](C)O)([H])NC([C@@H]3CCCN3C([C@@H
Molecular Weight	4241,9
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.