Brain Natriuretic Peptide (1-32)

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Brain Natriuretic Peptide (1-32) (human) (trifluoroacetate salt)

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Cat No: 24541

Biochemicals - Receptor Pharmacology

Brain natriuretic peptide (BNP) (1-32) is an endogenous peptide that has cardiovascular functions and belongs to the family of natriuretic peptides, which includes atrial natriuretic peptide (ANP; Item Nos. 24276
24539
24540) and C-type natriureti...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-?-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-L-histidine, cyclic (10?26)-disulfide, trifluoroacetate salt

Correlated keywords:

114471-18-0 132194-29-7 BNP32 nesiritide NPR-1 2 3 PGF-2? NPR1GCA GCA HEK-293 124584-08-3

Product Overview:
Brain natriuretic peptide (BNP) (1-32) is an endogenous peptide that has cardiovascular functions and belongs to the family of natriuretic peptides, which includes atrial natriuretic peptide (ANP; Item Nos. 24276
24539
24540) and C-type natriuretic peptide (CNP; Item No. 24401).{36488,39460} It is an agonist of natriuretic peptide receptors (NPRs) 1 and 3 with Kd values of 7.3 and 13 pM, respectively, for human chimeric extracellular receptors fused to the constant domain of IgG.{39460} It also binds to human recombinant NPR1, also known as guanylyl cyclase-A (GC-A), and NPR3 with IC50 values of 8 and 2.6 nM, respectively, in radioligand binding assays.{36489} It is selective for NPR1/GC-A and NPR3 over NPR2/GC-B (Kd = 30,000 pM). BNP (1-32) activates NPR1/GC-A and increases cGMP levels with an EC50 value of 27 nM in HEK293 cells expressing the human receptor and stimulates cGMP accumulation in cultured bovine aortic endothelial and aortic smooth muscle cells (EC50s = 9 and 17 nM, respectively).{36489,36490} It also relaxes contractions induced by prostaglandin F2α (PGF2α) in isolated porcine coronary artery and rat aortic strips (IC50s = 0.02 and 12.1 nM, respectively).{36491} In rats, BNP (1-32) (10 nmol/kg) increases mean urine flow and the sodium excretion rate. Formulations containing BNP (1-32) have been used in the treatment of acutely decompensated congestive heart failure.

Size	1 mg
Shipping	dry ice
Molecular Formula	C₁₄₃H₂₄₄N₅₀O₄₂S₄ • XCF₃COOH
SMILES	[H]N[C@@H](CO)C(N1CCC[C@H]1C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CO)C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CO)C(N[C@@H](CO
Molecular Weight	3464
Formulation	A lyophilized powder
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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