Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us
You are here :

L-trans-Pyrrolidine-2,4-dicarboxylic Acid

  • Zoom
    L-<em>trans</em>-<wbr/>Pyrrolidine-<wbr/>2,4-dicarboxylic Acid
  • L-<em>trans</em>-<wbr/>Pyrrolidine-<wbr/>2,4-dicarboxylic Acid
Cat No: 24268
Biochemicals - Receptor Pharmacology
Cayman

L-trans-Pyrrolidine-2,4-dicarboxylic acid (L-trans-2,4-PDC) is an inhibitor of L-glutamate transport (Ki = 4.6 μM in rat brain synaptosomes).{40981} It inhibits radioligand binding to NMDA receptors by 13% but has no effect on AMPA or kainate receptor...

More

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 2S,4R-pyrrolidinedicarboxylic acid
Correlated keywords:
  • trans-4-Carboxy-L-proline MK801
Product Overview:
L-trans-Pyrrolidine-2,4-dicarboxylic acid (L-trans-2,4-PDC) is an inhibitor of L-glutamate transport (Ki = 4.6 μM in rat brain synaptosomes).{40981} It inhibits radioligand binding to NMDA receptors by 13% but has no effect on AMPA or kainate receptors when used at a concentration of 100 μM. L-trans-2,4-PDC is neurotoxic to astrocyte-rich and astrocyte-poor rat cortical cultures (EC50s = 320 and 50 μM, respectively), an effect that can be reversed by the NMDA antagonist MK-801 (Item No. 10009019) and glutamate-pyruvate transaminase but not the non-NMDA glutamate receptor antagonist CNQX (Item No. 14618).{40982} It induces efflux of the non-metabolizable glutamate analog [3H]-D-aspartate in an extracellular sodium-dependent manner. In vivo, L-trans-2,4-PDC (0.05-0.2 μg/side) prevents amphetamine-induced hyperlocomotion in a dose-dependent manner in rats when injected directly into the nucleus accumbens.{40983} It also increases bladder intercontraction interval (ICI) without affecting postvoid residual or basal pressure in rats.{40984}
Size 1 mg
Shipping dry ice
CAS Number 64769-66-0
Molecular Formula C6H9NO4
SMILES OC([C@H]1NC[C@H](C(O)=O)C1)=O
Molecular Weight 159,1
Formulation A crystalline solid
Purity ≥98%
Custom Code 2918.99
UNSPSC code 12352100

Click here to ask for your quote and get 15% off Cayman's products.

 

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : L-<em>trans</em>-<wbr/>Pyrrolidine-<wbr/>2,4-dicarboxylic Acid There are 2 products.

Search