FSL-1 (trifluoroacetate salt)

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Cat No: 24220

Biochemicals - Receptor Pharmacology

FSL-1 is a synthetic lipopeptide agonist of toll-like receptor 2 (TLR2) and TLR6 heterodimers (TLR2/TLR6).{36662,36665} In HEK293 cells transfected with human TLR2 and TLR6 but not TLR6 alone, FSL-1 increases NF-κB activity by 4- and 8-fold when used ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-?-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine, trifluoroacetate salt

Correlated keywords:

FSL1 TLR-2 6 10 HEK-293 NF?B CCL-20 IL8 IL1? TNF? DM-13 VMM-1 CXCL-10 IL6 IFN? THP1 322455-70-9

Product Overview:
FSL-1 is a synthetic lipopeptide agonist of toll-like receptor 2 (TLR2) and TLR6 heterodimers (TLR2/TLR6).{36662,36665} In HEK293 cells transfected with human TLR2 and TLR6 but not TLR6 alone, FSL-1 increases NF-κB activity by 4- and 8-fold when used at concentrations of 0.1 and 1 nM, respectively.{36662} It induces the expression of the cytokines CCL20, IL-8, IL-1β, and TNF-α in human monocytic THP-1 cells and, to a lesser extent, in TLR10 knockdown cells when used at a concentration of 100 ng/ml.{36666} FSL-1 (0.5-50 μg/ml), in combination with IFN-γ, dose-dependently increases the percentage of DM13 and VMM1 melanoma cells expressing the chemokine CXCL10 with a maximal increase of approximately 50%.{36663} In rats, FSL-1 (100 μg/kg, i.p.) induces fever and increases plasma levels of IL-6 and TNF-α by greater than 90-fold.{36664} FSL-1 (10-1,000 μg/kg, i.p.) also dose-dependently reduces home cage locomotor activity and both food and water consumption with maximal reductions of ten grams per 12 hours.

Size	500 µg
Shipping	dry ice
Molecular Formula	C₈₄H₁₄₀N₁₄O₁₈S • XCF₃COOH
SMILES	O=C(O)[C@@H](NC([C@H](CO)NC([C@H](CCCCN)NC([C@H]1N(C([C@@H](NC([C@H](CCCCN)NC([C@@H]2CCCN2C([C@H](CC(O)=O)NC(CNC([C@@H](N)CSCC(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)CCC1)=O)=O)=O)CC4=CC=CC=C4.OC(C(F)(F)F)=O
Molecular Weight	1666,2
Formulation	A solid
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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ISO Guide 34:2009

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