Hesperadin

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Hesperadin

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Cat No: 24199

Hesperadin is a multi-kinase inhibitor.{42010,42011,18314} It inhibits human Aurora kinase B (IC50 = 250 nM) and its T. brucei homolog Aurora kinase-1 (IC50 = 40 nM) in in vitro kinase assays.{42010,42011} Hesperadin (1 µM) inhibits AMPK, LCK, MKK1, M...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[2,3-dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-ethanesulfonamide

Correlated keywords:

Hesperadine Trypanosoma MKK-1 MAPKAPK1 CHK-1 MEKK-2 Hep-G2 Leishmania Plasmodium

Product Overview:
Hesperadin is a multi-kinase inhibitor.{42010,42011,18314} It inhibits human Aurora kinase B (IC50 = 250 nM) and its T. brucei homolog Aurora kinase-1 (IC50 = 40 nM) in in vitro kinase assays.{42010,42011} Hesperadin (1 µM) inhibits AMPK, LCK, MKK1, MAPKAP-K1, CHK1, and PHK in a panel of 25 kinases.{42010} It also inhibits MEKK2 in ATPase and transphosphorylation assays with IC50s of 60 and 34 nM, respectively.{18314} Hesperadin (50-100 nM) induces polyploidy and defects in cytokinesis and spindle assembly as well as inhibits proliferation of HeLa cells and overrides mitotic arrest induced by paclitaxel (Item No. 10461) or monastrol (Item No. 15044).{42010} Hesperadin also induces toxicity in HepG2 cells with a toxic concentration (TC50) value of less than 0.2 µM.{42013} It inhibits replication of clinical isolates of influenza A and B viruses with EC50s ranging from 0.22 to 2.21 µM in a plaque formation assay.{42012} Hesperadin inhibits the growth of T. brucei, L. major promastigotes and amastigotes, and P. falciparum with EC50 values ranging from 0.01 to 2.37 µM, but has less activity against T. cruzi (EC50 = 39 µM).{42013}

Size	1 mg
Shipping	dry ice
CAS Number	422513-13-1
Molecular Formula	C₂₉H₃₂N₄O₃S
SMILES	O=C(NC1=C/2C=C(NS(CC)(=O)=O)C=C1)C2=C(NC3=CC=C(CN4CCCCC4)C=C3)\C5=CC=CC=C5
Molecular Weight	516,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2935.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.