Fondaparinux (sodium salt)

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Cat No: 24033

Biochemicals - Small Molecule Inhibitors

Fondaparinux is a pentasaccharide inhibitor of Factor Xa, the enzyme that activates prothrombin in the coagulation cascade (IC50s = 40, 45, and 36 nM for human, rabbit, and rat enzymes, respectively, in vitro).{38580} It binds to antithrombin III (Kds...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-?-D-glucopyranosyl-(1?4)-O-?-D-glucopyranuronosyl-(1?4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-?-D-glucopyranosyl-(1?4)-O-2-O-sulfo-?-L-idopyranuronosyl-(1?4)-2-deoxy-2-(sulfoamino)-?-D-glucopyranoside, 6-(hydrogen sulfate), decasodium salt

Correlated keywords:

104993-28-4 350014-67-4 Arixtra Fondaparin IC-851589 85158 IC851589 IC85158 Org31540 Org-31540 SR90107A Xantidar anti-thrombin

Product Overview:
Fondaparinux is a pentasaccharide inhibitor of Factor Xa, the enzyme that activates prothrombin in the coagulation cascade (IC50s = 40, 45, and 36 nM for human, rabbit, and rat enzymes, respectively, in vitro).{38580} It binds to antithrombin III (Kds = 48, 132, 78, and 50 nM for human, rabbit, baboon, and rat, respectively) and inhibits thrombin generation through the extrinsic and intrinsic routes (IC50s = 0.3 and 2.8 µM, respectively). Fondaparinux dose-dependently inhibits thrombus formation in a rabbit model of venous thrombosis with complete inhibition of clot formation at a dose of 200 µg/kg. Formulations containing fondaparinux have been used for prophylaxis of deep vein thrombosis following hip or knee replacement surgery.

Size	1 mg
Shipping	dry ice
CAS Number	114870-03-0
Molecular Formula	C₃₁H₄₃N₃O₄₉S₈ • 10Na
SMILES	O[C@H]1[C@H](O)[C@@H](COS([O-])(=O)=O)O[C@@](O[C@@H]2[C@@H](C([O-])=O)O[C@](O[C@H]3[C@H](OS([O-])(=O)=O)[C@@H](NS([O-])(=O)=O)[C@@H](O[C@]4([H])[C@H](C([O-])=O)O[C@@H](O[C@@]5([H])[C@H](O)[C@@H](NS([O-])(=O)=O)[C@@H](OC)O[C@@H]5COS([O-])(=O)=O)[C@H](OS([O
Molecular Weight	1728
Formulation	A solid
Purity	≥95%
Custom Code	2935.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.