Mafenide

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Mafenide

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Cat No: 23995

Mafenide is a sulfonamide antibiotic that inhibits growth of bacteria.{39511,39512} It inhibits growth of clinical isolates of S. pyogenes, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), Enterococcus, Enterobacteriac...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-(aminomethyl)-benzenesulfonamide

Correlated keywords:

Streptococcus Staphylococcus Klebsiella Pseudomonas Acinetobacter anti-biotic Sulfamylon NSC34632 Ambamide Homonal Homosul Mesudin Mesudrin Neofamid Paramenyl Septicid Sulfamylon Marprontil Mafylon toluenesulfonamide aminomethylbenzensulfonamide benzamsulfonamide emilene homosulfanilamide malfamin marfanil maphenid maphenide sulfamoylbenzylamine CAI CAII

Product Overview:
Mafenide is a sulfonamide antibiotic that inhibits growth of bacteria.{39511,39512} It inhibits growth of clinical isolates of S. pyogenes, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), Enterococcus, Enterobacteriaceae, and Gram-negative bacilli from burn patients in an agar well diffusion assay (mean zone of inhibition = 24-37 mm) but not in a broth dilution assay with MIC values ranging from 250 to greater than 5,000 μg/ml.{39511} Mafenide also inhibits growth of clinical isolates of K. pneumoniae that produce extended spectrum β-lactamase (ESBL), P. aeruginosa, and A. baumannii-calcoaceticus from burn patients in an agar well diffusion assay (mean zones of inhibition = 23.5, 28.9, and 25.8 mm, respectively) but not in a broth dilution assay (mean MICs = 1,024 μg/ml, 1,024 μg/ml, and 1,024 μg/ml, respectively).{39512} It decreases mortality in a rat model of burn wounds seeded with rat virulent P. aeruginosa.{39513} Mafenide also inhibits human carbonic anhydrase (CA) I and II (Kis = 41.91 and 0.612 μM, respectively).{39514} Formulations containing mafenide have been used in the treatment of severe burns.

Size	100 mg
Shipping	dry ice
CAS Number	138-39-6
Molecular Formula	C₇H₁₀N₂O₂S
SMILES	NCC1=CC=C(S(N)(=O)=O)C=C1
Molecular Weight	186,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2935.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.